diff --git a/telethon/client/updates.py b/telethon/client/updates.py
index 925b2b1b..ead9f944 100644
--- a/telethon/client/updates.py
+++ b/telethon/client/updates.py
@@ -341,6 +341,15 @@ class UpdateMethods:
                         self._updates_error = e
                         await self.disconnect()
                         break
+                    except errors.RPCError as e:
+                        # Fallback; treat as transient error (the amount of "fatal errors" reported seem to indicate this is most likely what we need to do)
+                        self._log[__name__].warning(
+                            "Cannot get difference due to unexpected error (this may be a bug "
+                            f"in Telethon v{__version__} in that it could be handled better, but it's unlikely): %s",
+                            e
+                        )
+                        self._message_box.end_difference()
+                        continue
                     except OSError as e:
                         # Network is likely down, but it's unclear for how long.
                         # If disconnect is called this task will be cancelled along with the sleep.
@@ -439,6 +448,19 @@ class UpdateMethods:
                             self._mb_entity_cache
                         )
                         continue
+                    except errors.RPCError as e:
+                        # Fallback; treat as transient error (the amount of "fatal errors" reported seem to indicate this is most likely what we need to do)
+                        self._log[__name__].warning(
+                            "Cannot get difference for channel %d due to unexpected error (this may be a bug "
+                            f"in Telethon v{__version__} in that it could be handled better, but it's unlikely): %s",
+                            get_diff.channel.channel_id, e
+                        )
+                        self._message_box.end_channel_difference(
+                            get_diff,
+                            PrematureEndReason.TEMPORARY_SERVER_ISSUES,
+                            self._mb_entity_cache
+                        )
+                        continue
                     except OSError as e:
                         self._log[__name__].info(
                             'Cannot get difference for channel %d since the network is down: %s: %s',